Near the site of the current temple of Agia Ekaterini, above Loutro, traces of walls and buildings have been identified, belonging to the Ancient town of Anopolis, port of which was Katopoli or Phoenix, currently located in Loutro. Anopolis was an independent town and had its own currency.

During the Byzantine period it was still well developed, which is indicated by the many churches of the area. Later, during the Ottoman Era, Anopolis and the entire province of Sfakia, due to the intense mountainous terrain, was never inhabited by Turks.